Our Research & Initiatives

Our research focuses on the development of radiation-activated nanomedicine platforms to improve the precision and effectiveness of cancer therapy, with a primary emphasis on glioblastoma. We investigate polymeric nanoparticles that remain biologically inert until activated by ionizing radiation, enabling highly localized generation of cytotoxic oxyradicals within the tumor microenvironment. Through this approach, we study mechanisms of immune priming, therapeutic efficacy in hypoxic conditions, transient blood–brain barrier disruption, and selective, on-demand drug release. Our work integrates image-guided radiation delivery with nanoparticle activation to achieve spatially controlled treatment while minimizing off-target toxicity. By combining radiation oncology, photochemistry, nanotechnology, and molecular biology, our initiatives aim to advance next-generation cancer therapies that are safer, more precise, and translatable to clinical practice.